RELATIONSHIP BETWEEN ASTROCYTE ACTIVATION USING [11C]BU99008 PET, GLUCOSE METABOLISM AND AMYLOID IN ALZHEIMER’S DISEASE: A DEMENTIA PLATFORM UK EXPERIMENTAL MEDICINE STUDY
Zhen Fan, Valeria Calsolaro, Jim Mayers, Robin Tyacke, Ashwin Venkataraman, Grazia Daniela Femminella, Robert Perneczky, Roger N. Gunn, Eugenii A. Rabiner, Paul McMahan Matthews, David Nutt, Paul Edison
This study demonstrated a voxel-level correlation between [11C]BU99008 PET measuring astroglial metabolism consistent with astroglial activation and glucose metabolism in patients with AD/MCI subjects. The demonstration of positive and negative correlation between astroglial activation and cerebral glucose metabolism suggested that astroglial activation is heterogeneous across the AD brain.