BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.
Yen Ying Lim , Jason Hassenstab, Carlos Cruchaga, Alison Goate , Anne M. Fagan , Tammie L. S. Benzinger, Paul Maruff, Peter J. Snyder, Colin L. Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R. Farlow, Neill R. Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M. Ringman, Martin Rossor, Stephen Salloway, Peter R. Schofield, David M. Holtzman, John C. Morris, Randall J. Bateman on behalf of the Dominantly Inherited Alzheimer Network
Using participants from the DIAN study demonstrated that possessing one copy of the brain-derived neurotrophic factor (BDNF) Met 66 allele increased the severity of impairment in episodic memory and hippocampal function in preclinical autosomal dominant Alzheimer’s disease. The work shows that BDNF is important to the preclinical presentation of AD.