Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia
Francesco Paonessa, Lewis D. Evans, Ravi Solanki, Delphine Larrieu, Selina Wray, John Hardy, Stephen P. Jackson, Frederick J. Livesey
Highlights Tau mutations cause microtubule-mediated deformation of the nucleus in dementia Nuclear deformation results in defective nucleocytoplasmic transport Neuronal nuclei are deformed in the post-mortem frontotemporal dementia brain Disrupted nucleocytoplasmic transport is shared in multiple dementias