Work Package 4 – Amyloid discovery cohort

Insight 46 is a neuroimaging sub-study of the MRC National Survey of Health and Development (also known as the British 1946 birth cohort). For this sub-study, 502 participants were recruited to participate in two clinic visits in London. Data collection included cognitive, physical, and sensory assessments; blood, urine and cerebrospinal sample collections; and a positron emission tomography (PET)/magnetic resonance imaging (MRI) brain scan to assess amyloid (a brain protein linked with dementia) and brain structure. Study data are available through the DPUK Data Portal and the MRC Unit for Lifelong Health and Ageing with approval from the cohort owners.